Francis Esmonde-White

Francis' most recent work is focused on transcutaneous Raman spectroscopy and Raman tomography. In order to advance these spectroscopic methods, he has been working on several new technologies to enable optimization and testing of spectroscopy in people. His publications and presentations are listed below.

In addition to his research, he organized and chaired the Biomedical Raman spectroscopy sessions at the 2009 and 2010 FACSS conferences, and is currently a governing board member of the Coblentz society, as well as co-editor of the newsletter and editor of the web site.

Francis can be reached via email at francis@esmonde-white.com
See Francis's LinkedIn profile , academia.edu, Google Scholar profile, or his Mathworks profile (with user-contributed Matlab code).

Publications:

KA Esmonde-White, FWL Esmonde-White, MD Morris, BJ Roessler, Effects of pathology dyes on Raman bone spectraJournal of biomedical optics 18 (5), 057002-057002 (2013). DOI: 10.1117/1.JBO.18.5.057002 (SPIE link)

Francis W. L. Esmonde-White, Michael D. Morris, Validating in vivo Raman spectroscopy of bone in human subjects. Proc. SPIE (Photonic Therapeutics and Diagnostics IX), Vol. 8565, 85656K (2013). DOI: 10.1117/12.2005679 (SPIE link)

Francis W. L. Esmonde-White, Karen A. Esmonde-White, Matthew R. Kole, Steven A. Goldstein, Blake J. Roessler and Michael D. Morris, Biomedical tissue phantoms with controlled geometric and optical properties for Raman spectroscopy and tomography, Analyst, 2011, 136 (21), 4437 - 4446. DOI: 10.1039/C1AN15429J (analyst linkNote: The supplementary figures are available on the Analyst web site. 3D Figure ESI

Karen A. Esmonde-White, Francis W. L. Esmonde-White, Michael D. Morris and Blake J. Roessler, Fiber-optic Raman spectroscopy of joint tissues, Analyst, Vol. 136, Iss. 8, p. 1675-1685 (2011). DOI: 10.1039/C0AN00824A (analyst link)

Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris, Minor Distortions with Major Consequences: Correcting Distortions in Imaging Spectrographs. Applied Spectroscopy, Vol. 65, Iss. 1, p. 85 (2011). DOI: 10.1366/10-06040 (ingenta link, OSA link)

Jennifer-Lynn Demers ; Brian Pogue ; Frederic Leblond ; Francis Esmonde-White ; Paul Okagbare ; Michael MorrisAcquisition and reconstruction of Raman and fluorescence signals for rat leg imaging. Proc. SPIE (Multimodal Biomedical Imaging VI), Vol. 7892  789211 (2011). DOI: 10.1117/12.881104 (SPIE link)

Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris, Exposed and transcutaneous measurement of musculoskeletal tissues using fiber optic coupled Raman spectroscopy. Proc. SPIE (Optics in Bone Biology and Diagnostics), Vol. 7548F, 7548F147 (2010). DOI: 10.1117/12.843091 (SPIE link)

Paul I. Okagbare, Francis W.L. Esmonde-White, Steven A. Goldstein, Michael D. Morris, Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model. The Analyst, Vol. 135, p. 3142, (2010). DOI: 10.1039/c0an00566e (analyst link)

Gurjit S. Mandair, Francis W. Esmonde-White, Aaron M. Swick, Mohammed P. Akhter, Jaclynn Kreider, Steven A. Goldstein, Robert R. Recker, Michael D. Morris, Potential of Raman spectroscopy to evaluate bone quality in postmenopausal osteoporosis patients: first results of a perspective study. Proc. SPIE (Optics in Bone Biology and Diagnostics), Vol. 7548F, 7548F140 (2010). DOI: 10.1117/12.842515 (SPIE link)

Kathryn A. Dooley, Francis W. L. Esmonde-White, Michael D. Morris, Optical fiber bundle coupling errors in Raman spectra: correction via data processing. Proc. SPIE (Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry), Vol. 7560, 756015 (2010). DOI: 10.1117/12.842418 (SPIE link)

Francis W.L. Esmonde-White and Michael D. Morris, “Raman Imaging And Raman Mapping” in Emerging Applications of Raman Spectroscopy edited by Michael D. Morris and Pavel Matousek. Springer, 2010. DOI: 10.1007/978-3-642-02649-2_5 (Springer link)

Francis W.L. Esmonde-White and David H. Burns, A portable multi-wavelength near infrared photon time-of-flight instrument for measuring light scattering. Journal of Near Infrared Spectroscopy, Vol. 17, Iss. 4, p.167–176 (2009). DOI: 10.1255/jnirs.847 (JNIRS link)

Matthew V. Schulmerich, Jacqueline H. Cole, Jaclynn M. Kreider, Francis W.L. Esmonde-White, Kathryn A. Dooley, Steven A. Goldstein, and Michael D. Morris. Transcutaneous Raman Spectroscopy Of Murine Bone In Vivo. Applied Spectroscopy, Vol. 63, Iss. 3, p.286-295 (2009). DOI: 10.1366/000370209787599013 (ingenta link, OSA link)

Francis W.L. Esmonde-White, Matthew V. Schulmerich, Karen A. Esmonde-White, and Michael D. Morris, Automated Raman Spectral Preprocessing of Bone and Other Musculoskeletal Tissues. Proc. SPIE (Optics in Bone Biology and Diagnostics), Vol. 7166, 716605 (2009). DOI: 10.1117/12.809436 (SPIE link)

Karen A. Esmonde-White, Gurjit S. Mandair, Francis W.L. Esmonde-White, Farhang Raaii, Blake J. Roessler, and Michael D. Morris, Osteoarthritis screening using Raman spectroscopy of dried human synovial fluid drops. Proc. SPIE (Optics in Bone Biology and Diagnostics), Vol. 7166, 71660J (2009). DOI: 10.1117/12.810057 (SPIE link

Francis W.L. Esmonde-White, Robust spectroscopic quantification in turbid media. PhD Thesis, McGill University, 2008. (McGill Libraries link)

McGill University disclosure of invention: Burns, DH; Esmonde-White, F; Bandilla, D "Analysis of Light with Optical Orbital Angular Momentum for Characterization of Scattering Media", Oct. 2004.

Francis L.W. Esmonde-White; David H. Burns, Visualization of N-way data using two-dimensional correlation analysis. Vib. Spec. 36, 287-292 (2004). DOI: 10.1016/j.vibspec.2004.02.012 (ScienceDirect link)

Presentations:

Validating in vivo Raman spectroscopy of bone in human subjects, Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris. SPIE Photonics West, San Francisco, California, January 21-26, 2012.

Determining Optical Sampling Volumes in Turbid Media, Francis W.L. Esmonde-White, Karen A. Esmonde-White, Blake J. Roessler, Michael D. Morris. Eastern Analytical Symposium (EAS), New Brunswick, NJ, Nov 14-17, 2011.

Optimizing optical probes for tortuous sampling paths and scattering samples, Francis W. L. Esmonde-White, Ryan J. Garrone, Michael D. Morris. Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Annual Meeting, Reno, NV, Oct 2-7, 2011.

Non‐invasive Imaging and Tomography of Bone Composition and Mineralization using Raman Spectroscopy. Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris. Orthopaedic Research Society (ORS) Annual Meeting, Long Beach, CA, Jan 13-16, 2011.

Transcutaneous Raman Spectroscopy of Ex-Vivo Human Bone. Francis W. L. Esmonde-White, Karen A. Esmonde-White, Blake J. Roessler, Michael D. Morris. FACSS, Raleigh, North Carolina, October 17-21 2010. 

Transcutaneous Raman Spectroscopy and Raman Tomography: Transitioning from Microscopy to Small Animals to Humans for Non-Invasive Diagnostics. Francis W. L. Esmonde-White, Karen A. Esmonde-White, Jennifer-Lynn H. Demers, Subhadra Srinivasan, Martin E. Isabelle, Brian W. Pogue, Steven A. Goldstein, and Michael D. Morris. SPEC, Manchester, UK, June 26 - July 1 2010. 

Exposed and transcutaneous measurement of musculoskeletal tissues using fiber optic coupled Raman spectroscopy. Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris. SPIE Photonics West, San Francisco, California, January 23-28 2010. 

Potential of Raman spectroscopy to evaluate bone quality in postmenopausal osteoporosis patients: first results of a perspective study. Gurjit S. Mandair, Francis W.L. Esmonde-White, Aaron M. Swick, Mohammed P. Akhter, Jaclynn Kreider, Steven A. Goldstein, Robert R. Recker, Michael D. Morris. SPIE Photonics West, San Francisco, California, January 23-28 2010. 

Optical fiber bundle coupling errors in Raman spectra: correction via data processing. Kathryn A. Dooley, Francis W. L. Esmonde-White, Michael D. Morris. SPIE Photonics West, San Francisco, California, January 23-28 2010. 

Geometrically-Accurate Tissue Phantoms for Transcutaneous Raman Spectroscopy, Francis W.L. Esmonde-White, Karen A. Esmonde-White, Kathryn A. Dooley, Michael D. Morris. FACSS (Federation of Analytical Chemistry & Spectroscopy Societies), Louisville, KY, October 18-22 2009. 

Arthroscopic Raman spectroscopy for identification of damaged articular cartilage, Karen A. Esmonde-White, Francis W.L. Esmonde-White, Blake J. Roessler, Michael D. Morris. FACSS, Louisville, KY, October 18-22 2009. 

Automated Raman spectral preprocessing of bone and other musculoskeletal tissues, Francis W.L. Esmonde-White, Matthew V. Schulmerich, Karen A. Esmonde-White, Michael D. Morris. SPIE Photonics West, San Jose, California, January 24-29 2009. 

Osteoarthritis screening using Raman spectroscopy of dried human synovial fluid drops, Karen A. Esmonde-White, Gurjit S. Mandair, Francis W. Esmonde-White, Farhang Raaii, Blake J. Roessler, Michael D. Morris, Michael D. Morris. SPIE Photonics West, San Jose, California, January 24-29 2009. 

Estimation of Myoglobin Oxygen Saturation from Spectra of Cardiac Tissue using Multivariate Curve Resolution, Francis W.L. Esmonde-White, Lorilee S. L. Arakaki, Kenneth A. Schenkman, Wayne A. Ciesielski, David H. Burns. FACSS, Reno, NV, September 28-October 2 2008. 

Raman Spectroscopy, a New Tool for Early Diagnosis of Osteoarthritis, Karen A. Esmonde-White, Gurjit S. Mandair, Farhang Raaii, Francis W.L. Esmonde-White, Blake J. Roessler, Michael D. Morris. FACSS, Reno, NV, September 28-October 2 2008. 

Development of a Handheld System Using NIR Photon Time-of-Flight to Measure Optical Scattering, Francis Esmonde-White, David Burns. FACSS, Memphis, Tennessee, October 12-18 2007. 

A Non-Generational Genetic Algorithm for Automated Preprocessing and Wavelength Selection in Biospectroscopy, Francis Esmonde-White, David Burns. FACSS, Orlando, Florida, September 24-28 2006. 

Estimation of light scattering colloids using a portable photon time-of-flight spectrometer, Francis W.L. Esmonde-White, David H. Burns. Chemistry and Biochemistry Graduate Research Conference, Concordia University, Montreal, Quebec, Canada, 18-19 November 2005 

Development of a handheld system for photon time-of-flight analysis of turbid media, Francis Esmonde- White, David Burns. FACSS, Quebec City, Quebec, Canada, October 9-13 2005. 

Phase difference measurements for portable photon time-of-flight clinical instrumentation, Francis L.W. Esmonde-White, David H. Burns. Chemistry and Biochemistry Graduate Research Conference, Concordia University, Montreal, Quebec, Canada, November 2004 

Temporal Augmentation of Diffuse Reflectance Spectroscopic Measurements, David Burns, Claudia Gributs, Francis Esmonde-White, and Dirk Bandilla. 12th International Diffuse Reflectance Conference, Wilson College, Chambersburg, Pennsylvania, USA, August 2004. 

Calibration of tissue temperature from non-contact short wavelength NIR spectroscopy, Francis L.W. Esmonde-White, A. Fafara, D.H. Burns. SPEC2004, Rutgers University, Newark, Newark, New Jersey, USA, June 2004. 

Determination of Myoglobin and Hemoglobin oxygenation in phantoms and excised hearts using NIR spectroscopy and Multivariate Curve Resolution (MCR), Francis L.W. Esmonde-White, D. H. Burns, L. Arakaki, W. Ciesielski, K. Schenkman. Canadian Society of Chemistry (CSC) Conference, London, Ontario, Canada, May 2004. 

Internet Cameras as Detectors in Spectrophotometric Analyses, Francis Esmonde-White, Jianzhong Yu, Cameron Skinner, David H. Burns. Canadian Society of Chemistry (CSC) Conference, Ottawa, Ontario, Canada, August 2003. 

Two-dimensional correlation analysis of N-way data, Francis W.L. Esmonde-White, and David H. Burns. 2nd International Symposium on Two-Dimensional Correlation Spectroscopy, University of Nottingham, Nottingham, UK, August 2003. 

N - Way, Multivariate Curve Resolution of Near Infrared Spectra to Examine Molecular Bonding in Volume Phase Transition Polymers, David H. Burns, Francis Esmonde-White, Xiao He. 15th European Symposium on Polymer Spectroscopy, Knossos Royal Village, Heraklion, Crete, Greece, June 2003. 

Phase Transition Polymers as Dispersed Micro/Nanosensors in Scattering Media, David H. Burns, Olivier Collin, Francis Esmonde-White, CEW Gributs, C.H. Kuo. 15th European Symposium on Polymer Spectroscopy, Knossos Royal Village, Heraklion, Crete, Greece, June 2003. 

Investigation of a Possible Mechanism for the Formation of a Cyclotrisilene, Francis Esmonde-White and Heidi M. Muchall. Second Annual CERMM Symposium, Concordia University, Montreal, Quebec, Canada, January 2002. 

Possible mechanism for the formation of a cyclotrisilene, Francis Esmonde-White, Heidi M. Muchall. Physical Organic Mini-Symposium (POMS), York University, Toronto, Ontario, Canada, November 2001.