Karen Esmonde-White

Karen's most recent work is focused on clinical translation of Raman techniques. In order to advance these spectroscopic methods, she has been working on several new technologies to enable optimization and testing of spectroscopy in people. Her publications and presentations are listed below.

In addition to basic science research, Karen organized and chaired the first Drop Deposition and Dynamics session at the 2010 FACSS conference.

Karen can be reached via email at karen (at) esmonde-white (dot) com

PUBLICATIONS:

1.     Esmonde-White FWL, Esmonde-White KA, Morris MD. Minor Distortions with Major Consequences: Correcting Distortions in Imaging Spectrographs. Appl. Spectrosc. 2011; 65(1):85.

2.     Esmonde-White KA, Mandair GS, Raaii F, Jacobson JA, Miller BS, Urquhart AG, Morris MD, Roessler BJ, “Raman Spectroscopy of Synovial Fluid as a Tool for Diagnosing Osteoarthritis”,  J. Biomed. Opt. 2009, 14(3), 034013

3.     Esmonde-White KA, Le Clair SV, Roessler BJ, Morris MD, “Effect of Conformation and Drop Properties on Surface‑Enhanced Raman Spectroscopy of Dried Biopolymer Drops”. Appl Spectrosc 2008, 62(5):503-511.

4.     Dehring, KA, Crane NJ, Smukler AR, et al. “Identifying Chemical Changes to Subchondral Bone taken from Murine Knee Joints using Raman Spectroscopy”, Appl. Spectrosc., 2006, 60(10), 1134-1141

5.     Dehring, KA, Smukler AR, Roessler BJ, Morris MD, “Correlating Changes in Collagen Secondary Structure with Ageing and Defective Type II Collagen by Raman Spectroscopy”, Appl.Spectrosc., 2006, 60(4), 366-372

6.     Poole SK, Patel S, Dehring K, Workman H, Poole CF, “Determination of Acid Dissociation Constants by Capillary Electrophoresis”, invited review for J. Chromatog. A, 2004, 1037(1-2), 445-454

7.     Dehring KA, Workman HL, Miller KD, Mandagere A, Poole SK, “Automated Robotic Liquid Handling/Laser‑Based-Nephelometry System for High Throughput Measurement of Kinetic Aqueous Solubility”, J. Pharm. Biomed. Analy., 2004, 36(3) 447-456 

8.     Poole SK, Patel S, Dehring K, Workman H, Dong J, "Estimation of octanol-water partition coefficients for neutral and weakly acidic compounds by microemulsion electrokinetic chromatography using dynamically coated capillary columns” J. Chromatog. B., 2003, 793(2), 265-274 

BOOK CHAPTERS:

1.     Morris MD, Esmonde-White KA, Raghavan, M.Raman Scattering: Speciation and Analysis”, in “Encyclopedia of Raman Spectroscopy”, Andrews (ed.), 2008

2.     Morris MD, Schulmerich MV, Dooley KA, Esmonde-White KA, “Vibrational Spectroscopic Imaging of Hard Tissue”, in “Infrared and Raman Spectroscopic Imaging”, Salzer, Siesler (Eds.), 2008

PEER-REVIEWED CONFERENCE PROCEEDINGS:

1.     Esmonde-White FWL, Esmonde-White KA, Morris MD. Exposed and transcutaneous measurement of musculoskeletal tissues using fiber optic coupled Raman spectroscopy. In: Mandelis A, editor. Optics in Bone Biology and Diagnostics; 2010; San Francisco, CA: SPIE; 2010.

2.     Esmonde-White KA, Mandair GS, Esmonde-White FWL, Raaii F, Roessler BJ, Morris MD, “Osteoarthritis Screening  using Raman Spectroscopy of Dried Human Synovial Fluid Drops”, In: Optics in Bone Biology and Diagnostics: 2009; San Jose, CA, USA: SPIE; 2009

3.     Esmonde-White FWL, Schulmerich MV, Esmonde-White KA, Morris MD, “Automated Raman spectral preprocessing of bone and other musculoskeletal tissues”, In: Optics in Bone Biology and Diagnostics: 2009; San Jose, CA, USA: SPIE; 2009

4.     Esmonde-White KA, Mandair GS, Raaii F, Roessler BJ, Morris MD, “Raman spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee joint damage”. In: Biomedical Optical Spectroscopy: 2008; San Jose, CA, USA: SPIE; 2008: 68530Y.

5.     Dehring KA, Roessler BJ, Morris MD, “Correlating Chemical Changes in Subchondral Bone Mineral due to Aging or Defective Type II Collagen by Raman Spectroscopy”, in Advanced Biomedical and Clinical Diagnostic Systems V: 2007; San Jose, CA, USA: SPIE; 2007, 64301B

6.     Dehring KA, Mandair GS, Roessler BJ, Morris MD, “SERS Detection of Hyaluronic Acid: A Potential Biomarker for Osteoarthritis” in “New Approaches in Biomedical Spectroscopy”, ACS Symposium Book, 2006

7.     Mandair GS, Dehring KA, Roessler BJ, Morris MD, “Detection of Potential Osteoarthritis Biomarkers using Surface-Enhanced Raman Spectroscopy in the Near-Infrared”, in “Biomedical Vibrational Spectroscopy III: Advances in Research and Industry”, Proc SPIE 6093, 2006, 60930H-7

8.     Reshni KA, Morris MD, Johnson BN, Burns MA, “On-line Detection of Electrophoretic Separations on a Microchip by Raman Spectroscopy”, Micro Total Analysis Systems ’98, D. Jed Harrison and A. van den Berg, Eds. Kluwer, Dordrecht: 1998, 109-112

PRESENTATIONS:

  1. Esmonde-White KA, Esmonde-White FLW, Morris MD, Roessler BJ. Morphological and Chemical Analysis of Dried Biofluid Drops. Annual Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Meeting, Rayleigh, NC, October 17-21, 2010. Oral Presentation
  2. Esmonde-White KA, Esmonde-White FLW, Roessler BJ, Morris MD. Arthroscopic Raman Spectroscopy of Joint Tissues. SPEC Scientific Meeting, Manchester, UK, June 26-July 1, 2010. Oral Presentation
  3.  Esmonde-White FLW, Esmonde-White KA, Demers, J-L H, Srinivasan S, Isabelle  ME, Pogue BW, Goldstein SA, Morris MD. Transcutaneous Raman Spectroscopy and Raman Tomography: Transitioning from Microscopy to Small Animals to Humans for Non-Invasive Diagnostics. SPEC Scientific Meeting, Manchester, UK, June 26-July 1, 2010. Oral Presentation
  4. Esmonde-White KA, Esmonde-White FLW, Morris MD, Roessler BJ. Optical Clinical Tools for Musculoskeletal Tissue Disorders. University of Michigan Internal Medicine Research Day, Ann Arbor, MI, May 13-14, 2010. Poster Presentation
  5. Esmonde-White KA, Esmonde-White FWL, Roessler B, Morris MD. Arthroscopic Raman spectroscopy for identification of damaged articular cartilage. Annual Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Meeting, Louisville, KY, October 18-22, 2009. Poster Presentation
  6. Esmonde-White KA, Clay B, Morris MD. What Can A Dried Coffee Ring Tell Us About Biomedical Diagnostics? Microscopy and Raman Spectroscopy of Biofluid Drop Deposition. Annual FACSS Meeting, Louisville, KY, October 18-22, 2009. Poster Presentation
  7. Esmonde-White KA, Esmonde-White FWL, Roessler B, Morris MD. Arthroscopic identification of preclinical damage to musculoskeletal tissue using Raman spectroscopy. MICHR Annual Symposium, Ann Arbor, MI, October 16, 2009. Poster Presentation
  8. Esmonde-White KA, Mandair GS, Raaii F, Esmonde-White FWL, Jacobson JA, Miller BS, Urquhart AG, Roessler BJ, Morris MD. Chemical Fingerprinting of Synovial Fluid for Early Osteoarthritis Detection. Annual Meeting of the Orthopaedic Research Society (ORS), Las Vegas, NV, February 22-25. Poster Presentation
  9. Esmonde-White KA, Mandair GS, Esmonde-White FWL, Raaii F, Roessler BJ, Morris MD. Osteoarthritis Screening using Raman Spectroscopy of Dried Human Synovial Fluid Drops. SPIE Photonics West Meeting, San Jose, CA, January 24-29, 2009. Oral Presentation
  10. Esmonde-White K, Mandair G, Raaii F, Esmonde-White F, Jacobson J, Miller B, Urquhart A, Roessler B, Morris M. Measurements of Chemical Changes in Synovial Fluid using Drop Deposition/Raman Spectroscopy are Associated with Knee Osteoarthritis Severity. University of Michigan Graduate Engineering Symposium, Ann Arbor, MI, November 7, 2008. Oral and Poster Presentation. Session Chair, Biomedical Imaging.
  11. Esmonde-White KA, Mandair GS, Raaii F, Esmonde-White FWL, Roessler BJ, Morris MD. Raman spectroscopy, a New Tool for Early Diagnosis of Osteoarthritis. Annual FACSS Meeting, Reno, NV, September 28- October 2, 2008. Oral Presentation
  12. Esmonde-White KA, Mandair GS, Raaii F, Roessler BJ, Morris MD. Raman spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee joint damage. SPIE Photonics West Meeting, San Jose, CA, January 19-24, 2008. Poster Presentation
  13. Esmonde-White KA, Mandair GS, Roessler BJ, Morris MD. Surface-Enhanced Raman Spectroscopy Evidence for Hyaluronic Acid Polymer Entanglement at Nanoliter Volumes.  University of Michigan Graduate Engineering Symposium, Ann Arbor, MI, November 2, 2007. Poster presentation
  14. Esmonde-White KA, Mandair GS, Roessler BJ, Morris MD. Surface-Enhanced Raman Spectroscopy Evidence for Hyaluronic Acid Polymer Entanglement at Nanoliter Volumes. Annual FACSS Meeting, Memphis, TN, October 14-18, 2007. SAS Student Poster Award and Oral Presentation
  15. Dehring KA, Roessler BJ, Morris MD. Correlating Chemical Changes in Subchondral Bone Mineral due to Aging or Defective Type II Collagen by Raman Spectroscopy. SPIE Photonics West Meeting, San Jose, CA, January 20-25, 2007. Poster Presentation
  16. Dehring KA, Mandair GS, Roessler BJ, Morris MD. Development of a Surface-Enhanced Raman Spectroscopy Protocol for Identification of Potential Osteoarthritis Biomarkers. Annual FACSS Meeting, Lake Buena Vista, FL, September 24-28, 2006. Poster Presentation
  17. Dehring KA, Smukler AS, Roessler BJ, Morris MD. Correlating Changes in Collagen Secondary Structure with Aging and Defective Type II Collagen by Raman Spectroscopy, Midwest Biomedical Engineering Conference, Ann Arbor, MI, March 23,2006. Poster Presentation
  18. Mandair GS, Dehring KA, Roessler BJ, Morris MD. Detection of Potential Osteoarthritis Biomarkers using Surface-Enhanced Raman Spectroscopy in the Near-Infrared. SPIE Photonics West Meeting, San Jose, CA, January 21-26, 2006. Oral Presentation
  19. Dehring KA, Smukler AS, Roessler BJ, Morris MD. Raman Spectroscopy of Ocular Tissue as a Probe for Articular Cartilage Collagen Damage. Annual FACSS Meeting, Quebec City, QC, October 9‑13, 2005. Poster Presentation
  20. Dehring KA, Smukler AS, Roessler BJ, Morris MD.  Raman Spectroscopy of Wild‑type and Transgenic Mouse Femoral Tissue Yield Molecular Markers for Osteoarthritis and Biomechanical Information on Matrix Deformation. Midwest Tissue Engineering Consortium Meeting, Cleveland, OH April 14-16 2005. Poster Presentation
  21.  Dehring KA, Seadeek C, Samas B. A Comparison of Automated Solubility Methods Used in the Early-Discovery and Lead-Seeking Stages of Ann Arbor Compound Development. 2004 Anachem.
  22. Kindt E, Kurzyniec S, Yapa U, Stankovic C, Glynn S, Dehring K. Development of a Rapid Method for pKa Determination of Compounds in Drug Discovery using Capillary Electrophoresis Tandem Mass Spectrometry with Cassette Injections. 2003 ASMS.
  23. Dehring KA Rapid Kinetic Solubility Measurements by Robotic Liquid Handling Coupled With Nephelometric Detection. 2003 Strategies for Improving Solubility Conference. Invited Speaker
  24. Dehring KA, Patel SS, Workman HL, Poole SK, Pfizer Analytical Symposium, 2002 Poster
  25. Dehring KA, Kale UJ, Ando HY, Pfizer Analytical Symposium, 2000 Poster
  26. Bright RM, Reshni KA, Morris MD, et.al., Pittsburgh Conference, 1999 Oral Presentation
  27. Reshni KA, Bright RM, Morris MD, et.al., Frederick Conference, 1998 Poster
  28.  Reshni KA, Bright RM, Morris MD, et.al., Micro-Total Analysis Systems, 1998 Poster
  29.  Morris MD, Bright RM, Reshni KA. FACSS, 1998 Oral Presentation
  30. Reshni KA, Walker PA, Morris MD, Pittsburgh Conference, 1998 Oral Presentation