Karen's most recent work is focused on clinical translation of Raman techniques. In order to advance these spectroscopic methods, she has been working on several new technologies to enable optimization and testing of spectroscopy in people. Her publications and presentations are listed below.
Karen can be reached via email at karen (at) esmonde-white (dot) com
PUBLICATIONS:1.
Esmonde-White FWL, Esmonde-White KA, Morris MD.
Minor Distortions with Major Consequences: Correcting Distortions in Imaging
Spectrographs. Appl. Spectrosc. 2011; 65(1):85.
2.
Esmonde-White KA, Mandair GS, Raaii F, Jacobson
JA, Miller BS, Urquhart AG, Morris MD, Roessler BJ, “Raman Spectroscopy of
Synovial Fluid as a Tool for Diagnosing Osteoarthritis”, J. Biomed. Opt. 2009, 14(3), 034013
3.
Esmonde-White KA, Le Clair SV, Roessler BJ,
Morris MD, “Effect of Conformation and
Drop Properties on Surface‑Enhanced Raman Spectroscopy of Dried Biopolymer
Drops”. Appl Spectrosc 2008,
62(5):503-511.
4. Dehring,
KA, Crane NJ, Smukler AR, et al. “Identifying Chemical Changes to Subchondral
Bone taken from Murine Knee Joints using Raman Spectroscopy”, Appl. Spectrosc.,
2006, 60(10), 1134-1141
5. Dehring,
KA, Smukler AR, Roessler BJ, Morris MD, “Correlating Changes in Collagen
Secondary Structure with Ageing and Defective Type II Collagen by Raman
Spectroscopy”, Appl.Spectrosc., 2006,
60(4), 366-372
6. Poole SK, Patel S, Dehring K, Workman H,
Poole CF, “Determination of Acid Dissociation Constants by Capillary
Electrophoresis”, invited review for J. Chromatog. A, 2004, 1037(1-2), 445-454
7. Dehring
KA, Workman HL, Miller KD, Mandagere A, Poole SK, “Automated Robotic Liquid
Handling/Laser‑Based-Nephelometry System for High Throughput Measurement of
Kinetic Aqueous Solubility”,
J. Pharm. Biomed. Analy., 2004,
36(3) 447-456
8. Poole
SK, Patel S, Dehring K, Workman H, Dong J, "Estimation of octanol-water
partition coefficients for neutral and weakly acidic compounds by microemulsion
electrokinetic chromatography using dynamically coated capillary columns” J.
Chromatog. B., 2003, 793(2),
265-274
BOOK CHAPTERS:
1.
Morris MD, Esmonde-White KA, Raghavan, M.”Raman
Scattering: Speciation and Analysis”, in “Encyclopedia of Raman Spectroscopy”,
Andrews (ed.), 2008
2.
Morris MD, Schulmerich MV, Dooley KA,
Esmonde-White KA, “Vibrational Spectroscopic Imaging of Hard Tissue”, in
“Infrared and Raman Spectroscopic Imaging”, Salzer, Siesler (Eds.), 2008
PEER-REVIEWED CONFERENCE PROCEEDINGS:
1.
Esmonde-White FWL, Esmonde-White KA, Morris MD.
Exposed and transcutaneous measurement of musculoskeletal tissues using fiber
optic coupled Raman spectroscopy. In: Mandelis A, editor. Optics in Bone
Biology and Diagnostics; 2010; San Francisco, CA: SPIE; 2010.
2.
Esmonde-White KA, Mandair GS, Esmonde-White FWL,
Raaii F, Roessler BJ, Morris MD, “Osteoarthritis Screening using Raman Spectroscopy of Dried Human
Synovial Fluid Drops”, In: Optics in Bone
Biology and Diagnostics: 2009; San
Jose, CA, USA: SPIE; 2009
3. Esmonde-White
FWL, Schulmerich MV, Esmonde-White KA, Morris MD, “Automated Raman spectral
preprocessing of bone and other musculoskeletal tissues”, In: Optics in Bone Biology and Diagnostics: 2009; San Jose, CA, USA: SPIE; 2009
4.
Esmonde-White KA, Mandair GS, Raaii F, Roessler
BJ, Morris MD, “Raman spectroscopy of
dried synovial fluid droplets as a rapid diagnostic for knee joint damage”.
In: Biomedical Optical Spectroscopy: 2008; San Jose, CA, USA: SPIE; 2008: 68530Y.
5. Dehring
KA, Roessler BJ, Morris MD, “Correlating Chemical Changes in Subchondral Bone
Mineral due to Aging or Defective Type II Collagen by Raman Spectroscopy”, in Advanced Biomedical and Clinical Diagnostic
Systems V: 2007; San Jose, CA, USA: SPIE; 2007, 64301B
6.
Dehring KA, Mandair GS, Roessler BJ, Morris
MD, “SERS Detection of Hyaluronic Acid: A Potential Biomarker for
Osteoarthritis” in “New Approaches in Biomedical Spectroscopy”, ACS Symposium
Book, 2006
7. Mandair
GS, Dehring KA, Roessler BJ, Morris MD, “Detection of Potential Osteoarthritis
Biomarkers using Surface-Enhanced Raman Spectroscopy in the Near-Infrared”, in
“Biomedical Vibrational Spectroscopy III: Advances in Research and Industry”,
Proc SPIE 6093, 2006, 60930H-7
8.
Reshni KA, Morris MD, Johnson BN, Burns MA,
“On-line Detection of Electrophoretic Separations on a Microchip by Raman
Spectroscopy”, Micro Total Analysis Systems ’98, D. Jed Harrison and A.
van den Berg, Eds. Kluwer, Dordrecht: 1998, 109-112
PRESENTATIONS:
- Esmonde-White
KA, Esmonde-White FLW, Morris MD, Roessler BJ. Morphological and Chemical Analysis of Dried Biofluid Drops. Annual Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Meeting, Rayleigh, NC, October 17-21, 2010. Oral Presentation
- Esmonde-White KA, Esmonde-White FLW,
Roessler BJ, Morris MD. Arthroscopic Raman Spectroscopy of Joint Tissues.
SPEC Scientific Meeting, Manchester, UK, June 26-July 1, 2010. Oral
Presentation
- Esmonde-White
FLW, Esmonde-White KA, Demers, J-L H, Srinivasan S, Isabelle ME, Pogue BW, Goldstein SA, Morris MD. Transcutaneous Raman Spectroscopy and Raman
Tomography: Transitioning from Microscopy to Small Animals to Humans for
Non-Invasive Diagnostics. SPEC Scientific Meeting, Manchester, UK, June
26-July 1, 2010. Oral Presentation
- Esmonde-White KA, Esmonde-White FLW, Morris
MD, Roessler BJ. Optical Clinical Tools for Musculoskeletal Tissue
Disorders. University of Michigan Internal Medicine Research Day, Ann
Arbor, MI, May 13-14, 2010. Poster Presentation
- Esmonde-White KA, Esmonde-White FWL,
Roessler B, Morris MD. Arthroscopic Raman spectroscopy for identification
of damaged articular cartilage. Annual Federation of Analytical Chemistry
and Spectroscopy Societies (FACSS) Meeting, Louisville, KY, October 18-22,
2009. Poster Presentation
- Esmonde-White
KA, Clay B, Morris MD. What Can A
Dried Coffee Ring Tell Us About Biomedical Diagnostics? Microscopy and
Raman Spectroscopy of Biofluid Drop Deposition. Annual FACSS Meeting, Louisville, KY, October 18-22,
2009. Poster Presentation
- Esmonde-White KA, Esmonde-White FWL, Roessler
B, Morris MD. Arthroscopic identification of preclinical damage to
musculoskeletal tissue using Raman spectroscopy. MICHR Annual Symposium,
Ann Arbor, MI, October 16, 2009. Poster Presentation
- Esmonde-White KA, Mandair GS, Raaii F,
Esmonde-White FWL, Jacobson JA, Miller BS, Urquhart AG, Roessler BJ,
Morris MD. Chemical Fingerprinting of Synovial Fluid for Early
Osteoarthritis Detection. Annual Meeting of the Orthopaedic Research
Society (ORS), Las Vegas, NV, February 22-25. Poster Presentation
- Esmonde-White KA, Mandair GS, Esmonde-White
FWL, Raaii F, Roessler BJ, Morris MD. Osteoarthritis Screening using Raman
Spectroscopy of Dried Human Synovial Fluid Drops. SPIE Photonics West
Meeting, San Jose, CA, January 24-29, 2009. Oral Presentation
- Esmonde-White K, Mandair G, Raaii F,
Esmonde-White F, Jacobson J, Miller B, Urquhart A, Roessler B, Morris M.
Measurements of Chemical Changes in Synovial Fluid using Drop
Deposition/Raman Spectroscopy are Associated with Knee Osteoarthritis
Severity. University of Michigan Graduate Engineering Symposium, Ann
Arbor, MI, November 7, 2008. Oral and Poster Presentation. Session Chair,
Biomedical Imaging.
- Esmonde-White KA, Mandair GS, Raaii F,
Esmonde-White FWL, Roessler BJ, Morris MD. Raman spectroscopy, a New Tool for Early Diagnosis of Osteoarthritis.
Annual FACSS Meeting, Reno, NV, September 28- October 2, 2008. Oral
Presentation
- Esmonde-White KA, Mandair GS, Raaii F,
Roessler BJ, Morris MD. Raman
spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee
joint damage. SPIE Photonics West Meeting, San Jose, CA, January
19-24, 2008. Poster Presentation
- Esmonde-White KA, Mandair GS, Roessler BJ,
Morris MD. Surface-Enhanced Raman Spectroscopy Evidence for Hyaluronic
Acid Polymer Entanglement at Nanoliter Volumes. University of Michigan Graduate
Engineering Symposium, Ann Arbor, MI, November 2, 2007. Poster
presentation
- Esmonde-White KA, Mandair GS, Roessler BJ,
Morris MD. Surface-Enhanced Raman Spectroscopy Evidence for Hyaluronic
Acid Polymer Entanglement at Nanoliter Volumes. Annual FACSS Meeting,
Memphis, TN, October 14-18, 2007. SAS Student Poster Award and Oral
Presentation
- Dehring KA, Roessler BJ, Morris MD.
Correlating Chemical Changes in Subchondral Bone Mineral due to Aging or
Defective Type II Collagen by Raman Spectroscopy. SPIE Photonics West
Meeting, San Jose, CA, January 20-25, 2007. Poster Presentation
- Dehring KA, Mandair GS, Roessler BJ, Morris
MD. Development of a Surface-Enhanced Raman Spectroscopy Protocol for
Identification of Potential Osteoarthritis Biomarkers. Annual FACSS
Meeting, Lake Buena Vista, FL, September 24-28, 2006. Poster Presentation
- Dehring KA, Smukler AS, Roessler BJ, Morris
MD. Correlating Changes in Collagen Secondary Structure with Aging and
Defective Type II Collagen by Raman Spectroscopy, Midwest Biomedical
Engineering Conference, Ann Arbor, MI, March 23,2006. Poster Presentation
- Mandair GS, Dehring KA, Roessler BJ, Morris
MD. Detection of Potential Osteoarthritis Biomarkers using
Surface-Enhanced Raman Spectroscopy in the Near-Infrared. SPIE Photonics
West Meeting, San Jose, CA, January 21-26, 2006. Oral Presentation
- Dehring KA, Smukler AS, Roessler BJ, Morris
MD. Raman Spectroscopy of Ocular Tissue as a Probe for Articular Cartilage
Collagen Damage. Annual FACSS Meeting, Quebec City, QC, October 9‑13,
2005. Poster Presentation
- Dehring KA, Smukler AS, Roessler BJ, Morris
MD. Raman Spectroscopy of Wild‑type
and Transgenic Mouse Femoral Tissue Yield Molecular Markers for
Osteoarthritis and Biomechanical Information on Matrix Deformation.
Midwest Tissue Engineering Consortium Meeting, Cleveland, OH April 14-16
2005. Poster Presentation
- Dehring
KA, Seadeek C, Samas B. A Comparison of Automated Solubility Methods Used in
the Early-Discovery and Lead-Seeking Stages of Ann Arbor Compound Development.
2004 Anachem.
- Kindt E, Kurzyniec S, Yapa U, Stankovic C, Glynn S, Dehring K. Development
of a Rapid Method for pKa Determination of Compounds in Drug Discovery using
Capillary Electrophoresis Tandem Mass Spectrometry with Cassette Injections.
2003 ASMS.
- Dehring
KA Rapid Kinetic Solubility Measurements by Robotic Liquid Handling Coupled
With Nephelometric Detection. 2003 Strategies for Improving Solubility
Conference. Invited Speaker
- Dehring
KA, Patel SS, Workman HL, Poole SK, Pfizer Analytical Symposium, 2002 Poster
- Dehring
KA, Kale UJ, Ando HY, Pfizer Analytical Symposium, 2000 Poster
- Bright
RM, Reshni KA, Morris MD, et.al., Pittsburgh Conference, 1999 Oral Presentation
- Reshni
KA, Bright RM, Morris MD, et.al., Frederick Conference, 1998 Poster
- Reshni KA, Bright RM, Morris MD, et.al., Micro-Total Analysis Systems, 1998 Poster
- Morris MD, Bright RM, Reshni KA. FACSS, 1998 Oral Presentation
- Reshni KA, Walker PA, Morris MD, Pittsburgh Conference, 1998 Oral Presentation
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