Karen's Publications & Presentations
Karen A. Esmonde-White, Lisa M. Ganster, and Ian R. Lewis. In-Process Raman Spectroscopy of Layered Materials. Spectroscopy Feb 2017 33(2): 16. (Spectroscopy Link)
Esmonde-White KA, Cuellar M, Uerpmann C, Lenain B, Lewis IR, Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing Anal Bioanal Chem. 2017 Jan;409(3):637-649. doi: 10.1007/s00216-016-9824-1. Epub 2016 Aug 4. (PubMed Link, Springer Link)
Karen A. Esmonde-White. Raman Spectroscopy as a Tool for Analytical Quality Control in a Hospital Environment. Spectroscopy June 2016. 31(6): 18–29,44. (Spectroscopy Link)
Megan E. Oest, Bo Gong, Karen Esmonde-White, Kenneth A. Mann, Nicholas D. Zimmerman, Timothy A. Damron, and Michael D. Morris, Parathyroid Hormone Attenuates Radiation-Induced Increases in Collagen Crosslink Ratio at Periosteal Surfaces of Mouse Tibia. Bone. 2016 May; 86: 91–97. doi: 10.1016/j.bone.2016.03.003 (PubMed Link, Elsevier Link)
Holly J Butler, Lorna Ashton, Benjamin Bird, Gianfelice Cinque, Kelly Curtis, Jennifer Dorney, Karen Esmonde-White, Nigel J Fullwood, Benjamin Gardner, Pierre L Martin-Hirsch, Michael J Walsh, Martin R McAinsh, Nicholas Stone, Francis L Martin. Using Raman spectroscopy to characterize biological materials Nature Protocols volume 11, pages 664–687 (2016). doi: https://doi.org/10.1038/nprot.2016.036 (Nature Protocols Link)
JL Demers, FW Esmonde-White, KA Esmonde-White, MD Morris, BW Pogue, Next-generation Raman tomography instrument for non-invasive in vivo bone imaging. Biomed Opt Express. 2015 Feb 11;6(3):793-806. doi: https://doi.org/10.1364/BOE.6.000793. eCollection 2015 Mar 1. (PubMed link, OSA link)
William R. Lloyd, Shailesh Agarwal, Sagar U. Nigwekar,Shawn Fagan, Jeremy Goverman, Karen Esmonde-White, Shawn Loder, Bjorn R. Olsen, Dolrudee Jumlongras, Michael D. Morris, Benjamin Levi, Raman spectroscopy for label-free identification of calciphylaxis. Journal of Biomedical Optics 20(8), 080501 (11 August 2015). doi: https://doi.org/10.1117/1.JBO.20.8.080501 . (SPIE Link)
Karen Esmonde-White, Raman Spectroscopy of Soft Musculoskeletal Tissues. Applied Spectroscopy Vol. 68, Issue 11, pp. 1203-1218 (2014) doi: 10.1366/14-07592 (PubMed Link)
KA Esmonde-White, FWL Esmonde-White, MD Morris, BJ Roessler, Characterization of biofluids prepared by sessile drop formation. Analyst. 2014 Jun 7;139(11):2734-41. doi: https://doi.org/10.1039/c3an02175k. (PubMed Link, RSC link)
Karen Esmonde-White, Francis Esmonde-White. Raman spectroscopy in biomineralization in Biomineralization sourcebook, (edited by Elaine DiMasi, Laurie B. Gower), CRC Press, Boca Raton, 2014 (CRC Press)
KA Esmonde-White, FWL Esmonde-White, CM Holmes, MD Morris, BJ Roessler, Alterations to bone mineral composition as an early indication of osteomyelitis in the diabetic foot. Diabetes Care. 2013 Nov;36(11):3652-4. doi: https://doi.org/10.2337/dc13-0510. Epub 2013 Aug 6. (PubMed Link, Diabetes Care link)
KA Esmonde-White, FWL Esmonde-White, MD Morris, BJ Roessler, Effects of pathology dyes on Raman bone spectra, Journal of biomedical optics 18 (5), 057002-057002 (2013). doi: https://doi.org/10.1117/1.JBO.18.5.057002 (PubMed Link, SPIE link)
Francis W. L. Esmonde-White, Michael D. Morris, Validating in vivo Raman spectroscopy of bone in human subjects. Proc. SPIE (Photonic Therapeutics and Diagnostics IX), Vol. 8565, 85656K (2013). doi: https://doi.org/10.1117/12.2005679 (SPIE link)
Karen A. Esmonde-White, Karen A. Esmonde-White, Joseph Sottnik, Joseph Sottnik, Michael Morris, Michael Morris, Evan Keller, Evan Keller, Raman spectroscopy of bone metastasis, Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82076P (17 February 2012); doi: https://doi.org/10.1117/12.909327 (SPIE Link)
Francis W. L. Esmonde-White, Karen A. Esmonde-White, Matthew R. Kole, Steven A. Goldstein, Blake J. Roessler and Michael D. Morris, Biomedical tissue phantoms with controlled geometric and optical properties for Raman spectroscopy and tomography, Analyst, 2011, 136 (21), 4437 - 4446. doi: https://doi.org/10.1039/C1AN15429J (PubMed Link, analyst link) Note: The supplementary figures are available on the Analyst web site. 3D Figure ESI
Karen A. Esmonde-White, Francis W. L. Esmonde-White, Michael D. Morris and Blake J. Roessler, Fiber-optic Raman spectroscopy of joint tissues, Analyst, Vol. 136, Iss. 8, p. 1675-1685 (2011). doi: https://doi.org/10.1039/C0AN00824A (PubMed Link, RSC link)
Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris, Minor Distortions with Major Consequences: Correcting Distortions in Imaging Spectrographs. Applied Spectroscopy, Vol. 65, Iss. 1, p. 85 (2011). doi: https://doi.org/10.1366/10-06040 (PubMed Link, OSA link)
Jennifer-Lynn Demers ; Brian Pogue ; Frederic Leblond ; Francis Esmonde-White ; Paul Okagbare ; Michael Morris, Acquisition and reconstruction of Raman and fluorescence signals for rat leg imaging. Proc. SPIE (Multimodal Biomedical Imaging VI), Vol. 7892 789211 (2011). doi: https://doi.org/10.1117/12.881104 (SPIE link)
Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris, Exposed and transcutaneous measurement of musculoskeletal tissues using fiber optic coupled Raman spectroscopy. Proc. SPIE (Optics in Bone Biology and Diagnostics), Vol. 7548F, 7548F147 (2010). doi: https://doi.org/10.1117/12.843091 (SPIE link)
Karen A. Esmonde-White, Raman Spectroscopy Detection of Molecular Changes Associated with Osteoarthritis. PhD Thesis, University of Michigan, 2009 (Univ. Michigan Libraries Link)
Esmonde-White KA, Mandair GS, Raaii F, Jacobson JA, Miller BS, Urquhart AG, Roessler BJ, Morris MD, Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis. J Biomed Opt. 2009 May-Jun;14(3):034013. doi: 10.1117/1.3130338. (PubMed Link, SPIE Link)
Francis W.L. Esmonde-White, Matthew V. Schulmerich, Karen A. Esmonde-White, and Michael D. Morris, Automated Raman Spectral Preprocessing of Bone and Other Musculoskeletal Tissues. Proc. SPIE (Optics in Bone Biology and Diagnostics), Vol. 7166, 716605 (2009). doi: https://doi.org/10.1117/12.809436 (SPIE link)
Karen Esmonde-White, Mekhala Raghavan, Michael Morris. Raman Scattering for Speciation and Analysis, in Encyclopedia of Applied Physics, Wiley, 2009. doi: 10.1002/3527600434.eap598.pub3 (Wiley Link)
Esmonde-White KA, Le Clair SV, Roessler BJ, Morris MD, Effect of conformation and drop properties on surface-enhanced Raman spectroscopy of dried biopolymer drops. Appl Spectrosc. 2008 May;62(5):503-11. doi: 10.1366/000370208784344370. (PubMed Link)
Karen A. Esmonde-White, Gurjit S. Mandair, Farhang Raaii, Blake J. Roessler, Michael D. Morris. Raman spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee joint damage. Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530Y (22 February 2008); doi: https://doi.org/10.1117/12.770360 (SPIE Link)
Michael D. Morris, Matthew V. Schulmerich, Kathryn A. Dooley, Karen A. Esmonde-White, Vibrational Spectroscopic Imaging of Hard Tissue, in Infrared and Raman Spectroscopic Imaging, Salzer, Siesler (Eds.), Wiley, 2008 (Wiley Link)
Karen A. Dehring, Blake J. Roessler, Michael D. Morris. Correlating chemical changes in subchondral bone mineral due to aging or defective type II collagen by Raman spectroscopy. Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301B (6 February 2007); doi: https://doi.org/10.1117/12.701095 (SPIE Link)
Dehring, KA, Crane NJ, Smukler AR, et al. Identifying Chemical Changes to Subchondral Bone taken from Murine Knee Joints using Raman Spectroscopy, Appl. Spectrosc., 2006, 60(10), 1134-1141. doi: 10.1366/000370206778664743 (PubMed Link)
Dehring, KA, Smukler AR, Roessler BJ, Morris MD, Correlating Changes in Collagen Secondary Structure with Ageing and Defective Type II Collagen by Raman Spectroscopy, Appl.Spectrosc., 2006, 60(4), 366-372. doi: 10.1366/000370206776593582 (PubMed Link)
Poole SK, Patel S, Dehring K, Workman H, Poole CF, Determination of Acid Dissociation Constants by Capillary Electrophoresis, invited review for J. Chromatog. A, 2004, 1037(1-2), 445-454. doi: 10.1016/j.chroma.2004.02.087 (PubMed Link)
Dehring KA, Workman HL, Miller KD, Mandagere A, Poole SK, Automated Robotic Liquid Handling/Laser Based Nephelometry System for High Throughput Measurement of Kinetic Aqueous Solubility, J. Pharm. Biomed. Analy., 2004, 36(3) 447-456. doi: 10.1016/j.jpba.2004.07.022 (PubMed Link)
Poole SK, Patel S, Dehring K, Workman H, Dong J, Estimation of octanol-water partition coefficients for neutral and weakly acidic compounds by microemulsion electrokinetic chromatography using dynamically coated capillary columns J. Chromatog. B., 2003, 793(2), 265-274. doi: 10.1016/S1570-0232(03)00321-0 (PubMed Link)
Esmonde-White KA, Mandair GS, Esmonde-White FWL, Raaii F, Roessler BJ, Morris MD, Osteoarthritis Screening using Raman Spectroscopy of Dried Human Synovial Fluid Drops, In: Optics in Bone Biology and Diagnostics: 2009; San Jose, CA, USA: SPIE; 2009
Esmonde-White KA, Mandair GS, Raaii F, Roessler BJ, Morris MD, Raman spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee joint damage. In: Biomedical Optical Spectroscopy: 2008; San Jose, CA, USA: SPIE; 2008: 68530Y.
Dehring KA, Roessler BJ, Morris MD, Correlating Chemical Changes in Subchondral Bone Mineral due to Aging or Defective Type II Collagen by Raman Spectroscopy, in Advanced Biomedical and Clinical Diagnostic Systems V: 2007; San Jose, CA, USA: SPIE; 2007, 64301B
Dehring KA, Mandair GS, Roessler BJ, Morris MD, SERS Detection of Hyaluronic Acid: A Potential Biomarker for Osteoarthritis in New Approaches in Biomedical Spectroscopy, ACS Symposium Book, 2006
Mandair GS, Dehring KA, Roessler BJ, Morris MD, Detection of Potential Osteoarthritis Biomarkers using Surface-Enhanced Raman Spectroscopy in the Near-Infrared, in Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, Proc SPIE 6093, 2006, 60930H-7
Reshni KA, Morris MD, Johnson BN, Burns MA, On-line Detection of Electrophoretic Separations on a Microchip by Raman Spectroscopy, Micro Total Analysis Systems ’98, D. Jed Harrison and A. van den Berg, Eds. Kluwer, Dordrecht: 1998, 109-112
Esmonde-White KA, Esmonde-White FLW, Morris MD, Roessler BJ. Morphological and Chemical Analysis of Dried Biofluid Drops. Annual Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Meeting, Rayleigh, NC, October 17-21, 2010. Oral Presentation
Esmonde-White KA, Esmonde-White FLW, Roessler BJ, Morris MD. Arthroscopic Raman Spectroscopy of Joint Tissues. SPEC Scientific Meeting, Manchester, UK, June 26-July 1, 2010. Oral Presentation
Esmonde-White FLW, Esmonde-White KA, Demers, J-L H, Srinivasan S, Isabelle ME, Pogue BW, Goldstein SA, Morris MD. Transcutaneous Raman Spectroscopy and Raman Tomography: Transitioning from Microscopy to Small Animals to Humans for Non-Invasive Diagnostics. SPEC Scientific Meeting, Manchester, UK, June 26-July 1, 2010. Oral Presentation
Esmonde-White KA, Esmonde-White FLW, Morris MD, Roessler BJ. Optical Clinical Tools for Musculoskeletal Tissue Disorders. University of Michigan Internal Medicine Research Day, Ann Arbor, MI, May 13-14, 2010. Poster Presentation
Esmonde-White KA, Esmonde-White FWL, Roessler B, Morris MD. Arthroscopic Raman spectroscopy for identification of damaged articular cartilage. Annual Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Meeting, Louisville, KY, October 18-22, 2009. Poster Presentation
Esmonde-White KA, Clay B, Morris MD. What Can A Dried Coffee Ring Tell Us About Biomedical Diagnostics? Microscopy and Raman Spectroscopy of Biofluid Drop Deposition. Annual FACSS Meeting, Louisville, KY, October 18-22, 2009. Poster Presentation
Esmonde-White KA, Esmonde-White FWL, Roessler B, Morris MD. Arthroscopic identification of preclinical damage to musculoskeletal tissue using Raman spectroscopy. MICHR Annual Symposium, Ann Arbor, MI, October 16, 2009. Poster Presentation
Esmonde-White KA, Mandair GS, Raaii F, Esmonde-White FWL, Jacobson JA, Miller BS, Urquhart AG, Roessler BJ, Morris MD. Chemical Fingerprinting of Synovial Fluid for Early Osteoarthritis Detection. Annual Meeting of the Orthopaedic Research Society (ORS), Las Vegas, NV, February 22-25. Poster Presentation
Esmonde-White KA, Mandair GS, Esmonde-White FWL, Raaii F, Roessler BJ, Morris MD. Osteoarthritis Screening using Raman Spectroscopy of Dried Human Synovial Fluid Drops. SPIE Photonics West Meeting, San Jose, CA, January 24-29, 2009. Oral Presentation
Esmonde-White K, Mandair G, Raaii F, Esmonde-White F, Jacobson J, Miller B, Urquhart A, Roessler B, Morris M. Measurements of Chemical Changes in Synovial Fluid using Drop Deposition/Raman Spectroscopy are Associated with Knee Osteoarthritis Severity. University of Michigan Graduate Engineering Symposium, Ann Arbor, MI, November 7, 2008. Oral and Poster Presentation. Session Chair, Biomedical Imaging.
Esmonde-White KA, Mandair GS, Raaii F, Esmonde-White FWL, Roessler BJ, Morris MD. Raman spectroscopy, a New Tool for Early Diagnosis of Osteoarthritis. Annual FACSS Meeting, Reno, NV, September 28- October 2, 2008. Oral Presentation
Esmonde-White KA, Mandair GS, Raaii F, Roessler BJ, Morris MD. Raman spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee joint damage. SPIE Photonics West Meeting, San Jose, CA, January 19-24, 2008. Poster Presentation
Esmonde-White KA, Mandair GS, Roessler BJ, Morris MD. Surface-Enhanced Raman Spectroscopy Evidence for Hyaluronic Acid Polymer Entanglement at Nanoliter Volumes. University of Michigan Graduate Engineering Symposium, Ann Arbor, MI, November 2, 2007. Poster presentation
Esmonde-White KA, Mandair GS, Roessler BJ, Morris MD. Surface-Enhanced Raman Spectroscopy Evidence for Hyaluronic Acid Polymer Entanglement at Nanoliter Volumes. Annual FACSS Meeting, Memphis, TN, October 14-18, 2007. SAS Student Poster Award and Oral Presentation
Dehring KA, Roessler BJ, Morris MD. Correlating Chemical Changes in Subchondral Bone Mineral due to Aging or Defective Type II Collagen by Raman Spectroscopy. SPIE Photonics West Meeting, San Jose, CA, January 20-25, 2007. Poster Presentation
Dehring KA, Mandair GS, Roessler BJ, Morris MD. Development of a Surface-Enhanced Raman Spectroscopy Protocol for Identification of Potential Osteoarthritis Biomarkers. Annual FACSS Meeting, Lake Buena Vista, FL, September 24-28, 2006. Poster Presentation
Dehring KA, Smukler AS, Roessler BJ, Morris MD. Correlating Changes in Collagen Secondary Structure with Aging and Defective Type II Collagen by Raman Spectroscopy, Midwest Biomedical Engineering Conference, Ann Arbor, MI, March 23,2006. Poster Presentation
Mandair GS, Dehring KA, Roessler BJ, Morris MD. Detection of Potential Osteoarthritis Biomarkers using Surface-Enhanced Raman Spectroscopy in the Near-Infrared. SPIE Photonics West Meeting, San Jose, CA, January 21-26, 2006. Oral Presentation
Dehring KA, Smukler AS, Roessler BJ, Morris MD. Raman Spectroscopy of Ocular Tissue as a Probe for Articular Cartilage Collagen Damage. Annual FACSS Meeting, Quebec City, QC, October 9-13, 2005. Poster Presentation
Dehring KA, Smukler AS, Roessler BJ, Morris MD. Raman Spectroscopy of Wild-type and Transgenic Mouse Femoral Tissue Yield Molecular Markers for Osteoarthritis and Biomechanical Information on Matrix Deformation. Midwest Tissue Engineering Consortium Meeting, Cleveland, OH April 14-16 2005. Poster Presentation
Dehring KA, Seadeek C, Samas B. A Comparison of Automated Solubility Methods Used in the Early-Discovery and Lead-Seeking Stages of Ann Arbor Compound Development. 2004 Anachem.
Kindt E, Kurzyniec S, Yapa U, Stankovic C, Glynn S, Dehring K. Development of a Rapid Method for pKa Determination of Compounds in Drug Discovery using Capillary Electrophoresis Tandem Mass Spectrometry with Cassette Injections. 2003 ASMS.
Dehring KA Rapid Kinetic Solubility Measurements by Robotic Liquid Handling Coupled With Nephelometric Detection. 2003 Strategies for Improving Solubility Conference. Invited Speaker
Dehring KA, Patel SS, Workman HL, Poole SK, Pfizer Analytical Symposium, 2002 Poster
Dehring KA, Kale UJ, Ando HY, Pfizer Analytical Symposium, 2000 Poster
Bright RM, Reshni KA, Morris MD, et.al., Pittsburgh Conference, 1999 Oral Presentation
Reshni KA, Bright RM, Morris MD, et.al., Frederick Conference, 1998 Poster
Reshni KA, Bright RM, Morris MD, et.al., Micro-Total Analysis Systems, 1998 Poster
Morris MD, Bright RM, Reshni KA. FACSS, 1998 Oral Presentation
Reshni KA, Walker PA, Morris MD, Pittsburgh Conference, 1998 Oral Presentation